EXPERTS IN DRUG DEVELOPMENT, CLINICAL PHARMACOLOGY AND PHARMACOMETRICS

Peer-Reviewed Publications

Al-Numani D, Scarsi C, Ducharme MP.

Levothyroxine soft capsules demonstrate bioequivalent pharmacokinetic exposure with the European reference tablets in healthy volunteers under fasting conditions.

Int J Clin Pharmacol Ther 2016;54(2):135-143.

Seng Yue C, Benvega S, Scarsi C, Loprete L, Ducharme M.

When bioequivalence in h ealthy volunteers may not translate to bioequivalence in patients: Differential effects of increased gastric pH on the pharmacokinetics of levothyroxine capsules and tablets.

J Pharm Pharm. Sci 2015;18(5):844-855.

Article gratuit

Al Numani D, Colucci P, Ducharme MP.

Rethinking bioequivalence and equivalence requirements of orally inhaled drug products.

Asian J Pharm. Sci2015;10:461-471.

Article gratuit

Ducharme MP.

Chapter 7: Drug Elimination, Clearance and Renal clearance. In : Shargel L, Yu A eds. Applied Biopharmaceutics and Pharmacokinetics, 7th edition.

McGraw Hill, 2015:149-175.

Seng Yue C, Ducharme MP.

Chapter 25 : Empirical models, mechanistic models and noncompartmental analysis. In : Shargel L, Yu A eds. Applied Biopharmaceutics and Pharmacokinetics, 7th edition.

McGraw Hill, 2015:817-849.

Colucci P, Ducharme MP.

Appendix A: Applications of software packages in Pharmacokinetics. In : Shargel L, Yu A eds. Applied Biopharmaceutics and Pharmacokinetics, 7th edition.

McGraw Hill, 2015:851-874.

Teng S, Potvin D, Mamputu JC, Vincent G, Zoltowska M, Morin J, Hatimi S, Michaud SE, High K, Ducharme MP.

Impact of Tesamorelin, a growth hormone-releasing factor (GRF) analogue, on the pharmacokinetics of simvastatin and ritonavir in healthy volunteers.

Clin Pharm Drug Dev 2013;2(3):237-245.

Seng Yue C, Gallicano K, Labbe, Ducharme MP.

Novel population pharmacokinetic method compared to the standard noncompartmental approach to assess bioequivalence of iron gluconate formulations.

J Pharm Pharm Sci2013;16(3):424-440.

Article gratuit

Gosai P, Ducharme MP, Godfrey AR, Freeman JC, Monif T, Kumar KS, Kumar S, Mudnaik R, Katikaneni P.

Bioequivalence of oxycodone hydrochloride extended release tablets to marketed reference products Oxycontin(R) in Canada and US. Int

J Clin Pharmacol Ther2013 May 14 (Epub ahead of print).

Colucci P, Seng Yue C, Ducharme M, Benvega S.

A review of the Pharmacokinetics of Levothyroxine for the Treatment of Hypothyroidism.

European Endocrinology 2013;9(1):40-47.

Article gratuit

Seng Yue C, Gandhi V, O’Brien S, Ravandi F, Jacobsen TF, Dirven H, Hagen S, Hals PA, Ducharme MP.

Novel Population Pharmacokinetic modeling of Arabinosyl Cytosine Triphosphate: Insights on potential preferential formation of Ara-CTP directly from Elacytarabine as well as from Ara-C.

Résumé gratuit ASH 2012

Yue CS, Scarsi C, Ducharme MP.

Pharmacokinetics and potential advantages of a new oral solution Levothyroxine vs. other available dosage forms.

Arzneimittelforschung 2012 Dec. 62(12):631-636.

Zeitlinger M, Rusca A, Oraha AZ, Gugliotta B, Muller M, Ducharme MP.

Pharmacokinetics of a new diclofenac sodium formulation developed for subcutaneous and intramuscular administration.

Int J Clin Pharmacol Ther 2012;50(6):383-390.

Ducharme MP, Hagen S, Halls PA, Jacobsen TF, Giles FJ, O'Brien SM, Dirven H, Colucci P, Seng Yue C.

Initial characterization of the toxicity and efficacy of elacytarabine (CP-4055), a novel antileukemic agent, using a multi-dimensional exposure-response relationship model.

J Clin Oncol 2012;30(Suppl):6619.

Résumé gratuit

Muller AC, Patnala S, Kis O, Bendayan R, Kanfer I.

Interactions between phytochemical components of Sutherlandia Frutescens and the Antiretroviral Atazanavir in vitro: Implications for absorption and metabolism.

J Pharm Pharm Sci2012;15(2))221-233.

Article Gratuit

Waldmann S, Almukainzi M, Bou-Chacra NA, Amidon GL, Lee BJ, Feng J, Kanfer I, Zuo JZ, Wei H, Bolger MB, Lobenberg R.

Provisional biopharmaceutical classification of some common herbs used in western medicine.

Mol Pharm 2012; Mar 14.

Chen ML, Shah VP, Crommelin DJ, Shargel L, Bashaw D, Bhatti M, Blume H, Dressman J, Ducharme M, Fackler P, Hyslop T, Lutter L, Morais J, Ormsby E, Thomas S, Tsang YC, Velagapudi R, Yu LX.

Harmonization of regulatory approaches for evaluating therapeutic equivalence and interchangeability of multisource drug products: Workshop Summary Report.

AAPS J 2011;13(4):556-564.

Article gratuit

Muller AC, Kanfer I.

Potential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and african traditional medicines.

Biopharm Drug Dispos 2011; 32(8):458-470.

Chen ML, Shah VP, Crommelin DJ, Shargel L, Bashaw D, Bhatti M, Blume H, Dressman J, Ducharme M, Fackler P, Hyslop T, Lutter L, Morais J, Ormsby E, Thomas S, Tsang YC, Velagapudi R, Yu LX.

Harmonization of regulatory approaches for evaluating therapeutic equivalence and interchangeability of multisource drug products: Workshop summary report.

Eur J Pharm Sci 2011;44:506-513.

Christie M, Lavergne V, Sikaneta T, Seng Yue C, Taskapan H, Tam PW, Ayoub P, Ting R, Leblanc D, Ghannoum M.

Hyperaluminemia during long-term dialysis: still relevant today.

Am J Kidney Dis. 2011 Nov;58(5):861-3.

Colucci P, Grenier J,Yue CS, Turgeon J, Ducharme MP.

Performance of different population pharmacokinetic algorithms.

Ther Drug Monit 2011 Oct;33(5):583-591.

Seng Yue C, Christie M, Lavergne V, Sikaneta T, Taskapan H, Mardini K, Tam P, Ting R, Ghannoum M.

Aluminum toxicokinetics in peritoneal dialysis patients.

Clin Toxicol (Phila). 2011 Aug; 49(7):659-63.

Colucci P, Turgeon J, Ducharme MP.

How critical is the duration of the sampling scheme for the determination of half-life, characterization of exposure and assessment of bioequivalence?

J Pharm Pharm Sci2011;14(2):217-226.

Article gratuit